• Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that affects various organ systems in the body, including the skin, joints, kidneys, and nervous system.
• In an individual with a healthy immune system, their body will usually produce antibodies that fight off antigens such as viruses and bacteria. However, in people with lupus, the immune system mistakenly attacks the body’s own healthy tissues, leading to inflammation, tissue damage, and pain via the production of auto-antibodies – antibodies that target the body’s own tissue.
• Lupus is a chronic inflammatory disease specifically targeting connective tissue – a type of tissue found throughout the body in every organ.
• It is estimated that 1 in 2000 people in the United States have SLE, and it is more common in women than in men.

Symptoms

The symptoms of SLE can vary quite drastically from person to person, and they may come and go over time.

Some common symptoms include:

• Fatigue
• Muscle pain
• Joint pain and swelling
• Skin rashes – including a butterfly-shaped rash on the face that spreads across the cheeks and nose
• Kidney problems
• Hair loss
• Fever
• Dry eyes
• Sensitivity to light including sunlight

SLE can also cause inflammation in various organs, leading to symptoms such as chest pain, shortness of breath, headaches, and issues with the functioning of those organs.

Testing and Diagnosis

There is no single test that can make a conclusive diagnosis of SLE. A physician will typically use a combination of blood tests and imaging studies, as well as certain physical exams to come to a diagnosis.

Some of the blood tests used to diagnose SLE are:

• Antinuclear antibody (ANA) test
• Anti-double-stranded DNA (anti-dsDNA) test
• Complete blood count (CBC) test.

Causes

The exact cause of SLE is not known, but studies suggest that it may be related to a combination of genetic and environmental factors

Certain risk-factors increase a person’s chance of developing Lupus such as a family history of the disease, exposure to certain chemicals, and infections.

There is also a type of  of drug-induced Lupus.

Complications

SLE can lead to a variety of complications due to the fact that the condition can cause inflammation is various organs. This can lead to damage to the including kidneys, heart and brain. SLE also raises one’s risk for infections, osteoporosis, and certain types of cancer.

• Renal Complications
  • A very serious complication of lupus is lupus nephritis, which is characterized by inflammation of the kidneys. This condition can lead to kidney failure if not treated quickly and effectively. Symptoms may include high blood pressure, darker or foamy urine, and swelling in the legs. A great remedy for this is Turmeric (see study)
• Cardiovascular Problems
  • Since Lupus increases the risk of cardiovascular disease, including heart attacks and strokes. The inflammation associated with lupus can affect the heart muscle, arteries, and heart membrane (pericarditis), which can potentially lead to life-threatening complications. To protect the heart, I strongly recommend herbs such as Hawthorn Berry and Arjuna as well as supplements such as Vitamin D, Vitamin K2, Magnesium, and Curcumin (learn more).
• Neurological and Mental Health Issues
  • Lupus can severely affect the nervous system, leading to complications such as headaches, dizziness, seizures, and even strokes. In addition, patients may experience psychological issues, including depression and anxiety, partly due to the stress of living with a chronic illness. Herbs such as Saffron (see study) and Curcumin (see study) may be of use in this case. Additionally, Magnesium, B-vitamins, and trace minerals may also assist with support nerve conductivity and neurological health,
• Musculoskeletal Complications
  • Joint pain and swelling are common in lupus patients and this can sometimes lead to long-term joint damage. In severe cases, lupus can cause arthritis, which can be quite debilitating. Remedies for this include Curcumin, Boswellia, and Black Seed (learn more).
• Pulmonary Issues
  • Lupus can affect the lungs, leading inflammation of the lining of the lung -> which is known as pleuritis as well as a condition known as pneumonitis (lung inflammation). These conditions can cause difficulty breathing and lower oxygen levels in the body. Herbs such as Caraway Seed (see study)and Thyme (see study) may help improve respiratory function and the inhalation of Eucalyptus may help open up the airways to improve breathing (see study). Honey can also help to expel excess mucus (see study).
• Blood Complications
  • Conditions such as anemia, a decrease in white blood cells (leukopenia), and a decrease in platelets (thrombocytopenia) can also occur. These conditions can increase the risk of infections and bleeding. Solutions for this include Wheatgrass juice and Papaya Leaf Extract (see study).
• Gastrointestinal Complications
  • Issues such as nausea, vomiting, and abdominal pain may also occur with Lupus. In some cases, it can cause inflammation of the liver or pancreas. For the liver, a great supportive tool is a product known as Liv. 52 by Himalaya. For managing digestive symptoms, Ginger and Fennel may be of use. The pancreas is a bit more complicated and I would highly recommend speaking to an Ayurvedic doctor about properly managing issues related to it.
• Increased Risk of Infection
  • Infections may occur due to the immune system’s dysfunction and the use of immunosuppressive medications. Ayurvedic formulas such as Chyavanprash (see study) and herbs such as Andrographis Paniculata (see study) may be particularly useful in this case as they are highly useful for supporting healthy immune function and fighting off infections.
• Pregnancy-Related Complications
  • Women with lupus unfortunately face a higher risk of complications during pregnancy, including conditions such as  pre-eclampsia, miscarriage, and preterm birth.

Types

There are several different types of SLE, including cutaneous lupus, which only targets the skin, and drug-induced lupus, which is caused by certain medications. SLE can affect different organ in different ways, leading to variations in symptoms it produces. This way the condition presents plays a strong role in determining the treatment options.

Remedies for Lupus

Some studies have suggested that fish oil and vitamin D supplementation may be beneficial for people with SLE.

Fish Oil

Fish oil is a popular supplement that is commonly used for reducing inflammation, improving cognitive and metabolic health, treating certain psychiatric conditions and more. It is rich is omega-3 essential fatty acids which are crucial for health.

In multiple clinical trials, Fish oil supplementation was associated with a significant improvement in disease activity and endothelial function as well as a reduction of oxidative stress in patients with SLE (1).

Vitamin D

Vitamin D is an essential fat-soluble vitamin that is responsible for a long list of highly important functions in the body from mineral metabolism to immune function. It tends to be deficient in a very large part of the population. Its deficiency has been linked to numerous illnesses including certain autoimmune conditions such as multiple sclerosis.

In a clinical trial, Vitamin D supplementation significantly decreased disease activity and improved fatigue in patients with SLE (2)

Ayurveda for Lupus

In Ayurvedic medicine, there are numerous options for managing autoimmune conditions. Some of the most popular herbal supplements such as Turmeric, Boswellia, Ashwagandha, Holy Basil, Tribulus, and Triphala all come from Ayurvedic medicine. In clinical research, Ayurvedic herbs and Ayurvedic treatment protocols have been found to be highly effective in a wide-range of autoimmune conditions such as Hyperthyroidism, Hashimoto’s Thyroiditis, Rheumatoid Arthritis, Diabetes Type 1, Aloepecia Areata, Vitiligo, Ulcerative Colitis and more.

In one clinical trial, Ayurvedic treatment resulted in a marked improvement of symptoms such as pain, oral ulcers and malar rash in patients with SLE  (3)

Ayurvedic management should always be done with the supervision of an Ayurvedic doctor.

Long-Term Use of Common Lupus Medications

Corticosteroids

Corticosteroids like prednisone are commonly prescribed for lupus due to their potent anti-inflammatory and immunosuppressive effects. Long-term use of these drugs, however, can lead to side effects such as:

• Osteoporosis: Prolonged use can weaken the bones which increases the risk of fractures.
• Weight Gain and Increased Appetite: They can also cause significant changes in metabolism and appetite.
• Increased Risk of Infections: Since corticosteroids suppress the immune system, they can make you more susceptible to infections.
• Cataracts and Glaucoma: These medications also increase your risk of developing eye problems.

Antimalarials

Drugs such as hydroxychloroquine are often used to prevent flares. They are generally considered safer for long-term use but can still have side effects such as:

• Retinal Damage: There is a risk of irreversible damage to the retina therefore regular eye exams should be done.
• Gastrointestinal Issues: Some people can experience stomach pain, nausea, or diarrhea.
• Skin Changes: In some cases, these medications can cause skin pigmentation changes.

Immunosuppressants

Immunosuppressants like azathioprine, methotrexate, and mycophenolate mofetil are used to control the immune system by suppressing its function. Long-term side effects include:

• Increased Risk of Infection: These drugs lower the body’s ability to fight infections.
• Liver Damage: These drugs are considered to be hepatotoxic, therefore, regular liver function testing should be done.
• Increased Risk of Cancer: These drugs are known to slightly increase your risk of certain types of cancer.

Biologics

Biologic therapies, like belimumab, are a somewhat new approach to lupus treatment. Long-term side effects are still being studied, but they may include:

• Injection Site Reactions: Pain, redness, and swelling at the injection site are common.
• Increased Risk of Infections: Just like other immunosuppressants, there’s an increased risk of acquiring infections.

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(Always use medicinal herbs under the supervision of a doctor)

by Dr. Nishal R.
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